Therapeutic vaccine candidates employing viral vectors encoding LMP2 have effectively induced virus-precise CD8⁺ T mobile responses in early-section clinical trials. In addition, adoptive T cell therapies like posoleucel also concentrate on LMP2 together with other latency proteins including EBNA1, reinforcing its significance being a conserved and immunodominant antigen.
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EBNA-3a–deficient LCLs proliferate much more gradually and exhibit amplified apoptosis when compared to wild-sort virus–derived LCLs.
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